He spent many years traveling in Spain, France and Belgium, where he corresponded with Erasmus and other learned men. He was also intimate with King John III and his sons, and acted as tutor to the Infante D. Duarte.
Resende enjoyed considerable fame in his lifetime, although his accuracy was later brought into question. In Portuguese he wrote:
His chief Latin work is the De Antiquitatibus Lusitaniae (Evora, 1593).
See the "Life" of Resende in Farinha's Collecção das antiguidades de Evora (1785), and a biographical-critical article by Rivara in the Revista Litteraria (Porto, 1839), iii. 340-62; also Cleynaerts, Latin Letters.
He is buried in the chapel of the right transept of the Cathedral of Évora, Portugal.