The history of Mesopotamia ranges from the earliest human occupation in the Lower Sumaya period up to the Late antiquity. This history is pieced together from evidence retrieved from archaeological excavations and, after the introduction of writing in the late 4th millennium BC, an increasing amount of historical sources. While in the Paleolithic and early Neolithic periods only parts of Upper Mesopotamia were occupied, the southern alluvium was settled during the late Neolithic period. Mesopotamia has been home to many of the oldest major civilizations, entering history from the Early Bronze Age, for which reason it is often dubbed the cradle of civilization.

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